With the rapid development of mobile Internet, mobile APP development technology, as a hot field, has become an important part of information technology education. This article takes the course of “Mobile APP Development Technology” as an example, starting from the necessity of practical innovation in course teaching, explores the problems existing in the current practical teaching of “Mobile APP Development Technology” course, and attempts to propose an innovative and reform approach based on the innovative curriculum system, practice before theory, upgrading teaching design, aligning with industry projects, establishing a multidimensional comprehensive evaluation system for practical teaching, and organizing teaching training to enhance teachers’ practical teaching ability. This "four in one" teaching method aims to improve students’ practical ability and innovative thinking and adapt to the needs of the future workplace.