There are many variables that influence the choice of structure of a characteristic building. In this dissertation, a qualitative comparative method was used to analyze the construction of a high-rise building whose character is residential, and which was constructed in three different ways and from three different types of structures: reinforced concrete, steel and composite steel and concrete structures. ETABS as Structural software is used for modeling and analysis of structural elements. All structural elements are designed according to Eurocodes with regard to all possible combinations of actions. In this dissertation, selected structural systems for different types of materials were applied according to the recommendations of the reviewed literature. In addition to the fact that the obtained results provide information on when and in which case it is better to choose a structure made of reinforced concrete, steel or composite steel and concrete structures, this information’s are so important, especially in the case of high-rise buildings, because it involves significant costs, i.e. significant savings, as time as well as material, if the right structure is chosen, which of course must meet other aspects prescribed by the standards, as well as the rules of the profession.