When I was asked to contribute an essay in honor of the 150th volume in the Philosophy and Medicine series, I asked myself, what could a philosopher and clinical ethicist who has spent most of her time teaching undergraduate biomedical ethics say that could contribute to discussions? Ah, herein is the start of an essay. In this essay, and in honor of the Philosophy and Medicine series’ 150th volume and 50th anniversary in publishing, I share what I say to my students in the classroom: there is a need for continued dialogue on the mutual dependence of biomedical ethics and philosophy of medicine within a global context. In what follows, I illustrate this mutual dependence of philosophy of medicine and biomedical ethics that is heralded in volumes in the Philosophy and Medicine series. I then illustrate this mutual dependence in discussions of philosophy of disease, a focus of my work for over three-plus decades now. As we celebrate the contributions of the Philosophy and Medicine series, we are reminded of its deep roots and lasting legacy in the literature.