With the increasing interdisciplinary nature of high-quality medical research, education, and clinical service, teamwork has become essential for achieving success as a medical school faculty member. Collegial interactions resulting from teamwork can make your career in academic medicine more productive and satisfying. You should be familiar with the characteristics of high-performing teams and strive to build, join, and lead such teams to optimize the efficacy, excellence, and efficiency of your work, as well as the scope and scale of your programs. Ongoing evaluation of the performance of your project teams is critical to continuously improve their function and success. Enhancing teamwork with the students, staff, and faculty who are involved in your programs is key to your personal achievement and advancing the mission of your organization. With the appropriate synergy, the whole can be greater than the sum of its parts.