Medical school faculty are a community, and collaboration among its members, especially across disciplines, is critical to the success of their programs and the institution. However, collaboration can be both beneficial and risky to your career advancement; it can significantly enhance the scope and scale of your activities and programs but potentially diminish the visibility and recognition of your individual contributions. As a collaborator, you should strive to demonstrate intellectual humility and avoid academic arrogance while being attentive to the success of your colleagues to ensure benefits to all. Effective communication and trust are essential in building successful collaborations. Ideally, members of a multidisciplinary team should complement each other by providing a range of knowledge, skills, and resources not otherwise available to each individually. At the outset of collaboration, each member’s role and responsibilities should be clearly defined, and recognition of anticipated contributions to publications, grant applications, patents, and other achievements agreed upon. Successful collaboration and teams should accomplish more together than the total of individual faculty accomplishments alone, i.e., the total should be greater than the sum of the parts.