The Chemistry Perfume (CP) course consists of three components: lectures, laboratory experiments, and research projects. Lecture studied about history, source, applies to industry, bioactivities, and the chemical components of the essential oil: terpenes, alcohol, aldehyde, ketone, esters, and aromatic derivatives. Laboratory experiments practice the skills of setting apparatus, preparing the concentration of chemicals, and using the high instruments. The research project used the 11 popular essential oils of berneol, camphor, menthol, eucalytal, citral, limonene, methyl salicylate, geraniol, thymol, and cinamondehyde as ingredients in cleaning products such as soaps, shampoos, and toothpaste. For effective learning, the QR code collected data on 11 components about the pharmacognosy, bioactivities, structures, and use in the cosmetics industry. In this study, 120 questionnaires were used to survey their choice of soap, sham-poo, and toothpaste, and these products contain herbal ingredients. Survey the number of soap, shampoo, and toothpaste products from three sources: con-venience stores, malls, and local markets. Consumers choosing natural products are in the age range of 38–60 years, accounting for 54 percent, and select prop-erties of the cleaning product aged 48–60 were 36 percent. The consumer in the age range of 48–60 years used QR codes is 22 percent. In this research, QR codes transferred knowledge about essential oils that are ingredients in soap, shampoo, and toothpaste products. QR codes will provide guidance for choosing cleaning products that are suitable for people. The process of the CP course used Project-Based Learning (PBL) is an educational approach for activated learning, engaging, understanding the students, and innovation for usefulness in the real world.