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Mutations in the DNA can affect cancer development and progression not only by changing the amino acid chain but also by affecting different regulatory elements such as transcription factors. This study presents a pipeline to identify mutation blocks—highly mutated genomic regions affecting transcription factors binding. Analysis of GCB lymphoma data revealed 56 mutation blocks affecting expression in key oncogenes such as BCL2, MYC, SGK1, PIM1 and linked to transcription factors such as MSC, TCFL5, HOXB7, FOXP3, ZBTB6. These mutation blocks suggest a selection for mutations that alter gene regulation, contributing to lymphoma development.

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Novel Driver Mutations in GCB Lymphoma Patients that Affect Transcription Factors Binding

  • 会议论文

  • 发表日期：

    2026年

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  • Ofek Shami-Schnitzer,
  • Tamir Tuller

摘要

Mutations in the DNA can affect cancer development and progression not only by changing the amino acid chain but also by affecting different regulatory elements such as transcription factors. This study presents a pipeline to identify mutation blocks—highly mutated genomic regions affecting transcription factors binding. Analysis of GCB lymphoma data revealed 56 mutation blocks affecting expression in key oncogenes such as BCL2, MYC, SGK1, PIM1 and linked to transcription factors such as MSC, TCFL5, HOXB7, FOXP3, ZBTB6. These mutation blocks suggest a selection for mutations that alter gene regulation, contributing to lymphoma development.