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Ventricular assist devices (VAD) are mechanical pumps that support heart failure patients as a bridge to heart transplantation or even destination therapy. Physiological control systems aim to improve the performance of these devices, facilitating long-term VAD implantation”. The representation of the cardiovascular systems (CVS) by numerical models is a good option for performing control simulations, an important object of research in the biomedical engineering field. This study introduces the initial stages of an open-source framework designed to simulate CVS coupled to a VAD numerical model. The aim is to assess how well physiological control systems work when applied to these devices. As a proof of concept, we simulated a CVS model with a VAD connected between the left ventricle and aorta (LVAD). Employing this coupled model (CVS+LVAD), we performed numerical simulations using a Starling-like controller, a control technique that uses the pump flow and the left ventricular end-diastolic pressure. The simulations produced the expected results according to the values of the simulated hemodynamic variables, demonstrating that the proposed methodology is adequate.

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Toward a Framework for Studies of Physiological Control Systems Applied to Ventricular Assist Devices

  • 会议论文

  • 发表日期：

    2025年

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  • R. A. Matos Júnior,
  • T. D. Cordeiro,
  • A. A. C. C. Sobrinho

摘要

Ventricular assist devices (VAD) are mechanical pumps that support heart failure patients as a bridge to heart transplantation or even destination therapy. Physiological control systems aim to improve the performance of these devices, facilitating long-term VAD implantation”. The representation of the cardiovascular systems (CVS) by numerical models is a good option for performing control simulations, an important object of research in the biomedical engineering field. This study introduces the initial stages of an open-source framework designed to simulate CVS coupled to a VAD numerical model. The aim is to assess how well physiological control systems work when applied to these devices. As a proof of concept, we simulated a CVS model with a VAD connected between the left ventricle and aorta (LVAD). Employing this coupled model (CVS+LVAD), we performed numerical simulations using a Starling-like controller, a control technique that uses the pump flow and the left ventricular end-diastolic pressure. The simulations produced the expected results according to the values of the simulated hemodynamic variables, demonstrating that the proposed methodology is adequate.