Femoral shaft fractures are quite common, especially in the elderly. They are easily stabilized using an intramedullary nailing device. Bone tissue is a living material and adapts its architecture depending on the volume of strain imposed on it. From a mechanical point of view, bone and nailing share the load, so bone remodeling stimulation can be partially compromised for those who didn’t have removed the nailing device after bone stabilization. The finite element software ANSYS was utilized to verify the strain distributions in a human femur with nailing. A walking step was replicated, using an expanded loading model, with the main muscular forces acting along the femur. An algorithm was used to measure the osteogenic response to the remodeling process. Despite the limitation of the applied model, the comparative analysis of the results, of three nailing materials, showed that the use of low-stiffness material increased the osteogenic stimulus over the bone. This study highlights the need to study not only the different loading protocols but also the geometries and materials applied to the implanted devices, aiming to minimize the amount of physical activity necessary for the osteogenic response.