sAs ultrasonic waves travel through biological tissues it causes medium vibration that induces changes in tissue permeability, causing therapeutic effects. The present work investigates the influence of tissue thickness on wave attenuation as ultrasound travels through each layer. Computer simulation implemented a multilayer model consisted of skin, fat, muscle, and bone. We find that the variation in thickness influences the amount of energy deposited in the tissue itself and subsequent tissues. Greater thicknesses absorb more energy. Other factors such as time, frequency, and intensity also modify the energy. The skin heats up more than that of the other tissues. Even though other tissues receive a lower concentration of heat, healthcare professionals cannot overlook the heating of tissue in therapeutic dosage due to its influence on treatment.