Objective: This study aimed to evaluate the effect of the Bag Squeezing maneuver on hemodynamic and ventilatory stability and respiratory mechanics in children under 5 years of age undergoing mechanical pulmonary ventilation. Methods: A non-controlled clinical trial was conducted with six sedated and paralyzed children diagnosed with respiratory failure. The Bag Squeezing protocol comprised 10 manual hyperinflation maneuvers alternated with 10 chest vibrocompression maneuvers. The bag was compressed with a 1 to 2-s inspiratory pause, followed by a swift release. Vibrocompression was executed with both hands under the child’s chest during the expiratory phase, followed by endotracheal tube, airways, and mouth suctioning, respectively. Hemodynamic and respiratory variables were recorded pre-maneuver and post-maneuver and after 30, 60, and 120 min. Results: Post-maneuver, heart rate did not exhibit significant elevation. Diastolic blood pressure increased by 30% (p = 0.001), and mean arterial pressure increased by 15% (p = 0.04), solely in the post-maneuver period. Exhaled carbon dioxide increased by 19% post-maneuver, without statistical differences between the observed intervals. Respiratory mechanics showed no significant alterations; however, 83.33% of children subjected to the maneuver demonstrated stability or an improvement of 1 to 2 cmH2O in static compliance and stability or reduction in airway resistance. Conclusion: The Bag Squeezing physiotherapy maneuver did not induce hemodynamic instability. The bag squeezing physiotherapy maneuver did not cause hemodynamic instability. SpO2, VTexh, MV, EtCO2, PmAW, Pplat, PEEPt, PEEPi variables did not show significant variations. Cst improved or remained stable after BS maneuver and in youngest child there was a significant reduction in Raw.