The aim of this study was to formulate a gel based on β-AgVO3 and validate its physicochemical stability. To this end, we began with the synthesis and characterization of β-AgVO3 and then obtained the gel. Centrifugation, accelerated stability (AS) and viscosity tests were performed. The β-AgVO3 powder was obtained in a yellow color. The gels were odorless, viscous and homogeneous. The SEM showed β-AgVO3 crystals with acicular geometry (needle-shaped), an average diameter of 100 nm and a length of micrometric order. After centrifugation, the β-AgVO3 gel showed maintenance of the organoleptic characteristics, viscosity and dispersion of the nanoparticles, indicating physicochemical stability. After AS, G1 showed physicochemical stability with maintenance of color, appearance and odor. G2 maintained its odorless characteristics and viscosity, but there was an intense color change; and both groups had a similar pH (P = 0.299). And G2 showed a decrease in viscosity when compared to G1. Thus, it was determined that the formulation showed physicochemical stability after centrifugation, viscosity and pH suitable for oral application and maintenance of organoleptic characteristics.