The artificial intelligence and blockchain technology presents a transformative opportunity for modern healthcare systems. This integration addresses critical challenges such as data security, privacy concerns, effective data exchange, patient confidentiality, and the inherent inefficiencies of centralized infrastructures. By combining the decentralized, immutable, and transparent structure of blockchain with the advanced analytics of AI, this synergy provides a powerful framework for secure, large-scale healthcare data management. Smart contracts, deployed on platforms like Ethereum, facilitate secure, automated transactions of sensitive medical data, reducing human error and enhancing overall reliability. This approach enhances privacy, improves data interoperability, ensures accountability, and optimizes overall system performance. This chapter investigates the multifaceted applications of AI and blockchain in healthcare, particularly focusing on data integrity and more fluid data-sharing protocols. It also delves into the key technical challenges, research directions, and the latest advancements shaping an integrated AI-blockchain ecosystem for healthcare data orchestration. Ultimately, the chapter demonstrates how the synergy between AI and blockchain can revolutionize healthcare data management, leading to more secure, efficient, and transparent healthcare systems.