The chapter addresses lymphatic filariasis (LF), a neglected tropical disease caused by nematode worms, such as Wuchereria bancrofti, affecting millions in tropical and subtropical regions. The disease, commonly known as elephantiasis in its chronic phase, leads to severe functional disability and deformity, with significant social and economic impacts. Although the World Health Organization (WHO) has implemented control programs to eradicate LF by 2030, transmission persists in some areas, particularly in Asia and isolated regions of Brazil. The chapter explores the clinical manifestations of LF, which range from asymptomatic to chronic conditions, such as lymphedema, hydrocele, and chyluria. Renal involvement in LF is also discussed, highlighting glomerular lesions, including membranous glomerulonephritis, with potential complications like persistent proteinuria. The importance of early detection, treatment with diethylcarbamazine (DEC), and the limited impact of this treatment on proteinuria are emphasized. It concludes that, despite advances in reducing transmission, filariasis still presents challenges, particularly in managing renal manifestations.