The differential diagnosis of chronic pain with numerous unclear symptoms such as fibromyalgia, irritable bowel syndrome, joint pain and back pain is complex. There is a broad spectrum of symptoms of very different degrees of severity. As doctors, we do not know exactly where the most diffuse pain comes from, whether it is acute or chronic, whether it even falls within our own speciality, what the somatic causes are and what complex psycho-social-biographical background we encounter. Patients need time, which is often in short supply. Healing is often not complete, and the support can be lengthy. This chapter shows a structured approach to simultaneous bio-psycho-social diagnostics, which also encourages the patient to actively participate in the sense of self-efficacy. The balance model from positive psychotherapy helps to gain a quick overview of the patient’s reality of life.