In this paper, the effects of four typical arrangements (row, diagonal, staggered and trapezoidal) on fire spread were investigated using a wood small low-rise building complex with three rows and three columns as an example. Fluent simulation was used to analyze the wind fields of the four arrangements in three wind directions (forward, diagonal, and sideways), and the most unfavorable wind directions were determined, and then PyroSim simulation was used to analyze the fire propagation characteristics of the four arrangements in the most unfavorable wind directions. The results show that the average and maximum wind speeds of the four arrangements are the smallest in the area under the forward wind, and the average and maximum wind speeds are the largest in the area under the diagonal wind. The fire spreads most slowly from the point of origin to the farthest place in the trapezoidal arrangement, and the time required is 1800s, while the time for the diagonal arrangement to spread to the farthest place is 1375s, the time for the staggered arrangement is 1120s, and the time for the row-array arrangement is 1005s.The average and maximum wind speeds of the wind field of the buildings under the three wind directions were greatest in the oblique wind direction, and the average and maximum wind speeds were least in the positive wind direction. The slowest fire spread in the building complex was in the trapezoidal arrangement, followed by the diagonal arrangement, followed by the staggered arrangement, and the worst performance was in the row arrangement.