One of the leading non-communicable diseases in the world in terms of morbidity and mortality is cardiovascular disease (CVD). Among other factors that may increase the risk of cardiovascular illness, contamination of food is emerging as a novel mechanism that may negatively impact the progression of atherosclerosis and related vascular repercussions. A balanced diet and lifestyle are useful in preventing cardiovascular disease, and there is evidence that they positively impact several risk factors for heart disease, stroke, and cardiometabolic health. To guarantee food security and positive outcomes, foods must be of the highest quality and safety. Foods may contain contaminants mostly due to human-initiated contamination or exposure from external factors (such as soil, water, or air pollution). Promoting heart wellness and the avoidance of diseases is a major responsibility of medical professionals and community leaders, but they also need a foundational understanding of nutrition. To radically alter the present-day diet and the worldwide food system, a coordinated effort from every level of society will be required. This chapter highlights the categories of food borne contaminants/toxins, mechanisms of Cardiovascular impacts, Key Toxins and Case Studies, and the prevention and Public Health Strategies.