Sustainability has become one of the most pressing challenges of the twenty-first century, requiring not only scientific and policy responses but also within the spiritual domains. While the importance of the ethical and spiritual domains is increasingly acknowledged in sustainability science, academic literature still offers limited engagement with examples of theological contributions, such as Laudato Si’. This chapter investigates how Pope Francis’s encyclical Laudato Si’ aligns with the three dimensions of sustainability (i.e., environmental, social, and economic) through a qualitative content analysis of its 36 sections. Our findings reveal that the encyclical concept of integral ecology challenges dominant technocratic paradigms and anthropocentric worldviews—by offering a spiritually grounded alternative rooted in Catholic Social Teaching. Notably, 17 sections addressed all three sustainability dimensions simultaneously, highlighting the encyclical’s potential to inform transformative action across academic, policy, and educational domains. Our study contributes to the interdisciplinary dialogue on sustainability by demonstrating how spiritual-ethical narratives can deepen our understanding of ecological responsibility, intergenerational justice, and integral human development.