A Modelling Study of Right Ventricular Dynamics with Valvular Regurgitation
摘要
Computational modelling of right ventricular (RV) dynamics and its response due to the regurgitation from tricuspid valve (TV) and pulmonary valve (PV) is understudied despite its equal importance as the left ventricle (LV). RV dysfunction can be very detrimental due to its limited functional reverse. In this study, we have developed an RV model using a patient-specific biventricular geometry by incorporating TV and PV, and further predicted RV structural and functional adaptation using a kinematic growth and remodelling framework. The results show that this model can capture the main characteristics of cardiac functions under TV and PV regurgitation, and can model RV dilation and thickening with the presence of TV and RV regurgitation if untreated. Personalized RV biomechanics models, once validated, have the potential to be integrated into clinical workflow for optimal patient management with RV dysfunction.