An Automatic Self-supervised Phase-Based Approach to Aligned Long-Axis Strain Measurements in Four Chamber Cardiovascular Magnetic Resonance Imaging
摘要
Cardiovascular Magnetic Resonance Imaging (cardiac MRI) is the gold standard for quantifying ventricular function, from which several parameters are derived. Among these, long-axis strain (LAS) is valuable for diagnosis of cardiovascular diseases. Unlike global longitudinal strain (GLS), which needs multi-plane imaging, LAS can be effectively derived from a single-plane four-chamber long-axis (4CH) cardiac MRI. Conventional analysis focuses on end-diastolic (ED) to end-systolic (ES) LAS, overlooking intermediate dynamics that could help distinguish diseases. In this study, we present a novel framework for estimating left ventricular LAS across five cardiac phases. The proposed method combines a self-supervised deformable image registration model for key frame detection with a supervised segmentation for landmark identification. LAS is calculated between ED and intermediate phases K (ED2K) and between consecutive phases (K2K). The methodology was developed and validated on the publicly available M&M2 dataset. The evaluation demonstrated significant differences between healthy individuals and patients with four of the seven cardiac diseases investigated not only in ED2ES, but also mid-systole to ES and ES to peak-flow. This emphasizes the diagnostic potential of phase-specific LAS analysis. The method is fully automated and fast, underscoring its potential for clinical application. The code and reference annotations will be made publicly available. https://github.com/Cardio-AI/cmr-las-phase2phase-analysis .