The integration of advanced imaging technologies and artificial intelligence (AI) is set to transform oral and craniomaxillofacial (CMF) surgery, a field focused on treating complex conditions such as congenital deformities, trauma, and head and neck oncology that affect the facial skeleton and soft tissues. Successful outcomes in these highly intricate procedures rely on precise preoperative planning and real-time intraoperative guidance. The synergy between medical imaging and AI is crucial in enhancing these processes, offering improved accuracy, efficiency, and patient outcomes. The aim of this chapter is to introduce the fundamentals of AI and the current state-of-the-art advancements in the field of oral and CMF surgery.