The integration of personalized implant design in cranio-maxillo-facial (CMF) surgery represents a transformative advancement, enabling tailored solutions that address complex anatomical and functional challenges. This chapter provides a comprehensive overview of the design and manufacturing processes, quality control, regulatory compliance, material selection, and clinical applications of patient-specific implants. Leveraging technologies such as computer-aided design, digital surgical planning, and additive manufacturing, personalized implants are precisely engineered to match a patient’s unique anatomy, offering superior precision, stability, and aesthetic outcomes compared to traditional methods. Experimental research has demonstrated the biomechanical and biological efficacy of personalized implants, emphasizing the importance of optimized pore structures, load distribution, and osseointegration in titanium and other materials. Emerging innovations in bioresorbable and bioceramic materials are set to further enhance regenerative capabilities. By addressing both clinical and material science perspectives, this chapter underscores the possibilities of personalized implants to improve surgical precision, patient recovery, and long-term outcomes in CMF surgery.