This concluding chapter discusses the concept that cognitive decline is neither preventable nor treatable; however, evidence supports the notion that it is preventable in many instances. The consequences of visceral fat are linked to AD decades before symptoms manifest. The biology and neuroanatomy of SuperAgers are discussed, as they resist age-related changes in cortical volume and memory, providing insight that may be useful in preventing or slowing down age-related cognitive impairments. The gut-brain axis and obesity as a modifiable disease are discussed. Lifestyle predicts dementia risk 20 years early. Conceptual recommendations to achieve aging successfully are enunciated. At the same time, it is recognized that more important than recipes is the understanding of lifestyle decisions and of the evolving knowledge that drives functional brain integrity. Beneficial diet, cognition, and successful aging ascertained by neuroimaging are discussed, as is the importance of social and emotional support. An analysis of evidence linking physical activity to improved health outcomes in aging is included. Overall, this chapter emphasizes that purpose, attitude, motivation, dedication, and resiliency are decisive for successful aging, counteracting cognitive dysfunctions and beneficially influencing the trajectory and quality of life.