The application of indigenous African philosophies to address some of the supply chain challenges especially those prevalent in the African context remains sparse in both research and practice. There is a dearth of literature on indigenous practices in the supply chain context in Africa. Majority of the strategies applied to solve African supply chain problems are not always contextually relevant. This chapter addresses this limitation by exploring the extent to which Ubuntu, an indigenous African philosophy on “humanness” can be integrated into African supply chain practices to ensure more socially focused and economically sustainable business operations. Specifically, the chapter focuses on how the Ubuntu philosophy presents a more nuanced understanding of supply chain concepts such as supplier selection, supply chain financing and supplier relationship management. This chapter specifically contributes by extending the Ubuntu debate into supply chain management theory, highlighting the application of Ubuntu concepts such as people centredness, permeable walls, partisanship, progeny and productivity alongside the contemporary supply chain theory that’s already well-enriched with western centric models. Related to practice, this chapter provides insights for possible supply chain strategies that managers and policy makers can consider for business that operate in the African environment.