In this chapter, I will look at the affective opportunities and resources for patients, families, and healthcare providers that may be facilitated by hospital design and architecture. Building upon the affective injustice discussion, theories on emotional design and architecture, and research in evidence-based design, I will suggest several ways that hospital design and architecture may improve well-being. In the first discussion, I will explore how hospital spaces, and in particular the hospital waiting area and the patient room, can facilitate greater emotional security. In the second, I will elaborate the room environment, notably the influence of light, color, and sound on the user’s affective experience. The third subject, inspired by architectural theorist Giuliana Bruno’s theory of e(motion), will explore the hospital space as vissuto, a space of lived experiences that invites us to rethink design and architecture to provide for greater user interaction.