Integrating Sustainable Development Goals (SDGs) into entrepreneurial ecosystems is crucial for fostering economic resilience, social equity, and environmental sustainability. This chapter explores the European Union’s approach to innovative entrepreneurship within the sustainable development framework, emphasizing best practices, policy mechanisms, and support structures. The research applies the SPAR (Situation, Problem, Action, Result) methodology to analyse the role of public–private partnerships, funding initiatives, and regulatory frameworks in fostering sustainable entrepreneurship. The study highlights the Dutch model as a leading example, demonstrating how strategic government support, strong networks, and an emphasis on circular economy principles and initiatives from universities contribute to a thriving ecosystem. Furthermore, it discusses the applicability of these European insights to developing economies, particularly Ukraine. The findings suggest that adopting direct and indirect government interventions, including financial incentives, international collaborations, and knowledge-sharing platforms, can enhance Ukraine’s innovation-driven growth. Ukraine can develop a resilient and competitive entrepreneurial landscape aligned with global sustainability goals by fostering sustainable business models and encouraging ecosystem-based cooperation.