In relation to the continuous social challenges that characterise contemporary society, safeguarding mental health is an emergency to which we are all called to respond. The role of political institutions in the promotion of mental health must not be limited to the provision of services, but must extend towards the creation of an environment conducive to the psychological well-being of the population, promoting a culture of well-being that starts as early as the educational cycle. In several foreign countries, many educational institutions have introduced meditation practices, such as Mindfulness, within the higher education cycle to promote well-being in the lives of their students. The proposed exploratory-comparative research aims to assess whether integrating Mindfulness into educational contexts with the support of AI-based applications can reduce e feelings of stress, anxiety, boredom and inattention that increasingly characterise the everyday life of Italian students. This approach, by combining meditation practices with digital technology, aims to create learning experiences that promote the subject’s physical and emotional well-being by providing generative settings for wellbeing and supporting mindful, embodied learning in the ‘here and now’.