Colon capsule endoscopy requires an optimized bowel preparation protocol to ensure adequate mucosal visualization and capsule progression before battery depletion. Effective preparation involves dietary adjustments, adjunctive laxatives, oral purgatives, prokinetic drugs, and boosters to improve adequate cleansing rates and completeness rates. Low-fiber diets, split-dose polyethylene glycol regimens, and boosters like sodium phosphate are key components of preparation. Recent evidence supports newer bowel preparation assessment scales such as CC-CLEAR, offering improved interobserver agreement and clinical relevance compared to earlier scales. This chapter provides a comprehensive review of bowel preparation strategies and cleansing quality evaluation for CCE, enabling evidence-based optimization for clinical and research applications.