The emerging field of human-plant interaction (HPI) explores how plants, both physically and virtually, establish connections with humans through digital technologies. This study examines the integration of hybrid horticultural therapy (HT) in promoting physical, mental, and cognitive health. First, the research outlines the concepts and status of HPI and HT. It then evaluates HT’s therapeutic effects across physical, psychological, social, and overall well-being, categorizing four key types: natural, digital, social, and comprehensive HT. Next, the study analyzes human, plant, and environmental attributes in hybrid HT, defining human roles, plant representations, and environmental interventions. A mechanism model of hybrid human-plant interaction is proposed, offering expanded applications for health interventions. Finally, the study assesses the advantages and limitations of hybrid HT, synthesizing interaction models, conceptual frameworks, and creative technologies. By envisioning its future applications, this research provides a novel perspective on human-plant relationships, revealing new pathways for health interventions through virtual and physical human-plant integration.