This study conducted a comparative analysis of multidisciplinary education models in science, technology, and the arts across five globally renowned institutions. By examining the curriculum structures, pedagogical approaches, and cultural influences, this research identified the strategies for integrating these fields in higher education. The key findings of this study indicate a paradigmatic shift towards disciplinary convergence, the universal adoption of project-based learning with culturally influenced variations, and the growing prominence of industry connections in educational programs. The research emphasizes the necessity of adapting global best practices to local contexts. This “glocal” approach is crucial for preparing students to address complex, real-world challenges in an increasingly interconnected world. The study offers valuable insights into the ongoing discourse on the future of higher education in a rapidly evolving technological landscape.