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Mitsugumin 53 (MG53), also known as TRIM72, is a member of the tripartite motif-containing (TRIM) protein family, which includes a conserved really interesting new gene (RING) domain, B-box domain, coiled-coil region, and C-terminal PRY- SplA and Ryanodine receptor (PRYSPRY) domain. It is predominantly expressed in skeletal and cardiac muscles in mice. Since its discovery in 2009, numerous studies have shown that MG53 plays a crucial role in cell membrane repair machinery. Its function in membrane repair involves facilitating the rapid resealing of damaged cellular membranes through interactions with phosphatidylserine (PS). In addition to membrane repair, MG53 regulates metabolic homeostasis and cellular signaling pathways utilizing its E3 ubiquitin ligase properties. Therapeutically, MG53 has been proven to protect tissues from injuries, including those in the heart, liver, lung, kidney, brain, skin, and muscle. Emerging evidence indicates that MG53 has antitumor effects in various cancers, such as lung cancer, pancreatic cancer, and colorectal cancer. MG53 may represent a potent adjuvant for treating therapy-resistant cancers. It is emerging as a versatile therapeutic target with applications in regenerative medicine and cancer, as well as related human diseases. The current review aims to summarize the latest literature concerning MG53 in light of its diverse functions in human diseases.

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The Multifaceted Functions of MG53: Orchestrating Tissue Repair and Its Implications in Cancer and Human Pathologies

  • 章节

  • 发表日期：

    2025年

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  • Zhongguang Li,
  • Fei Jiang,
  • Isabella Melians,
  • Matthew Bu,
  • Haichang Li

摘要

Mitsugumin 53 (MG53), also known as TRIM72, is a member of the tripartite motif-containing (TRIM) protein family, which includes a conserved really interesting new gene (RING) domain, B-box domain, coiled-coil region, and C-terminal PRY- SplA and Ryanodine receptor (PRYSPRY) domain. It is predominantly expressed in skeletal and cardiac muscles in mice. Since its discovery in 2009, numerous studies have shown that MG53 plays a crucial role in cell membrane repair machinery. Its function in membrane repair involves facilitating the rapid resealing of damaged cellular membranes through interactions with phosphatidylserine (PS). In addition to membrane repair, MG53 regulates metabolic homeostasis and cellular signaling pathways utilizing its E3 ubiquitin ligase properties. Therapeutically, MG53 has been proven to protect tissues from injuries, including those in the heart, liver, lung, kidney, brain, skin, and muscle. Emerging evidence indicates that MG53 has antitumor effects in various cancers, such as lung cancer, pancreatic cancer, and colorectal cancer. MG53 may represent a potent adjuvant for treating therapy-resistant cancers. It is emerging as a versatile therapeutic target with applications in regenerative medicine and cancer, as well as related human diseases. The current review aims to summarize the latest literature concerning MG53 in light of its diverse functions in human diseases.