Post-tuberculosis lung disease (PTLD) is emerging as a significant area of global interest and there remains a vast expanse of knowledge to be discovered. This study aims to enhance understanding of respiratory changes in individuals with PTLD through respiratory oscillometry. Results from 15 PTLD patients were compared with 15 controls. Significant increases were observed in respiratory resistance (p = 0.005), parameters reflecting ventilation heterogeneity (p < 0.001), and respiratory work (p < 0.001). A significant reduction was observed in dynamic compliance (p < 0.001). Receiver-operator curve analysis showed that the parameters obtained by oscillometry also presented adequate diagnostic accuracy (area under the curve > 0.90), indicating that this technique can be helpful in the evaluation of the respiratory mechanical alterations in patients with PTLD. In conclusion, oscillometry helps elucidate the biomechanical sequelae caused by pulmonary tuberculosis. Additionally, this method may accurately identify these abnormalities. Therefore, this method has significant potential in the functional assessment and the drug response in individuals with PTLD.