Coffee, a globally cherished beverage, has been extensively studied for its impact on health, including its intricate relationship with lipid metabolism. This chapter delves into the multifaceted effects of coffee consumption on lipid disorders, such as hypercholesterolemia and hypertriglyceridemia, which are significant risk factors for atherosclerotic cardiovascular diseases. Coffee’s diverse bioactive compounds—caffeine, diterpenes, polyphenols, and antioxidants—play pivotal roles in influencing lipid profiles and cardiovascular health. Variations in preparation methods and individual genetic predispositions further modulate these effects, underlining the importance of personalized dietary recommendations. While unfiltered coffee, rich in diterpenes, may elevate LDL cholesterol levels, filtered coffee exhibits favorable anti-atherogenic properties. Green coffee’s potential hypolipidemic benefits also emerge as a promising area of exploration. This synthesis aims to provide a comprehensive understanding of how coffee consumption can be tailored to maximize health benefits while mitigating potential risks.