Electronic waste is an increasing environmental challenge globally with different major implications for forensic toxicology. In the modern era, artificial intelligence and automated system chips and sensors are manufactured which also leads the electronic waste. Nowadays, even working equipment comes under E-waste as people are not able to resist chasing the latest technology and they are not aware that the formatting devices cannot delete the data permanently. In global problems one of the major problems is people do not know how and where we can dispose the E-waste material without spending too much money. Electronic trash contains different types of dangerous and harmful substances. By looking at routes from which the incineration, re-cycling, and dumping of electronic trash release these hazardous materials into the environment, the potential for bio-accumulates and bio-magnificent in various ecological compartments allows us to analyze how electronic waste affects the pollution of water, air, and soil quality. The threats to human health are caused by E-waste pollution exposure and the connections among the contaminants, carcinogenesis, and reproductive problems in humans. There are two ways of reducing the effects of e-waste toxicology techniques and analysis-based forensic investigations.