As cancer continues to pose a global threat, the need for the research in understanding the underlying mechanisms and feasible treatment becomes inevitable. In the research findings, DMBA has emerged as a strong carcinogen for inducing cancers of liver, intestine, pancreas, stomach, germ cell, skin, neural and many other types. The versatility of the zebrafish model enables the replication of various cancer types observed in humans, offering insights into the underlying mechanisms of cancer development. Furthermore, amidst the challenges posed by cancer, there is growing interest in exploring natural compounds for their potential anti-cancerous properties. Among phytochemicals, beta-carotene has gained attention as a possible anti-cancer drug. Commonly known as a precursor to vitamin A, many researches favour its role as an antioxidant and apoptosis inducing factor during cancer progression. This review highlights the suitability of zebrafish for studying carcinogenesis, particularly in the context of experiments involving 7,12-dimethylbenz[a]anthracene (DMBA), which induces a wide array of cancers in these organisms. The present study also summarizes that the beta-carotene exhibits beneficial effects in preventing cancer, potentially through its antioxidant and anti-inflammatory properties.