With the upgrading of industry and consumption, the research on human factors and UX innovation centered on human-centered value driving is getting more and more attention. Ergonomics and human-centered design (HCD) are both design methods that think about problems from the starting point of human needs. The paper took the development of intelligent game peripheral products as an example from the perspective of human-centered innovation, the concept of human-centered design was carried through the whole design process. The process and the methods of HCD and ergonomics were tried to combine. In order to find out the potential needs of the users and the design opportunity points, quantitative and qualitative methods of user research, such as anthropometric measurement and behavioral observation were used. It provided new ideas for innovative design and to provide new solutions for enterprise product development.