Silent Spring, a milestone book published in 1962, generated significant public attention about the harm of pesticides and the chemical industry to the environment. Popular movements were launched, leading to stricter regulations and the emergence of environmental communication, which has transformed from discourses on environmental stewardship and pesticide overuse to more pressing issues related to human existence, such as the water-energy-food (WEF) nexus. It is a relatively new approach to governing water, energy, and food systematically to balance their trade-offs, deemed by leading scientists and organizations as an effective solution to shortages, but less known to the public. Research is needed on how to effectively communicate the WEF nexus to the public for necessary awareness and support. This book, based on the National College Student Science Literacy Survey (NCSSLS) data, tests the functions of message levels and factors on levels of audience responses. It is intended for readers who are interested in (1) understanding the persuasiveness of popular message factors and audience responses at various levels; (2) communicating critical environmental issues, particularly the WEF nexus, effectively to the public; and (3) learning more about American college students, whose characteristics are captured in the NCSSLS data.