Individuals with autism spectrum disorder (ASD) often experience challenges with performing their daily living skills which may result in their limited participation in daily activities and dependence on their family. This paper presents the development and usability of a mobile-based interface supporting adults with ASD in everyday living. The application is called “DailyBuddy” and aims to support the independent living of autistic individuals via planning daily tasks (e.g., chores, groceries, and cooking), reminding them when tasks are due, and showing them how to perform daily living tasks. This study’s primary focus is investigating the effect of three different instructional methods (video prompting, image prompting, and a checklist) on user performance and preference. A total of 23 individuals on the autism spectrum (17 male and six female participants) participated in a between-subjects study. Our findings indicated the effectiveness of the daily living application in improving the quality of performing tasks. Although participants favored the checklist method more than others regarding user preference, the statistical analysis comparing the three instructional methods showed no significant difference. This information can improve the DailyBuddy application, enhance education, and increase independence for adults with autism.