The marginal visibility of African scientific contributions at the world stage calls to a question not only the robustness and quality of its graduate research, but also the capacity higher education institutions to gauge research ethics and integrity. The present chapter explores the state of research integrity in graduate research in Africa universities. In so doing, it draws on secondary data, review of scholarly and professional literature as well as research reports on research ethics focusing on African centers of knowledge and academic institutions. The findings shows that African HEIs running graduate programs are under increasing pressure due to violations of research ethics (RE) as a result of widespread contract cheating, plagiarism, fabrication, and falsification of data in masters’ theses and PhD dissertations; and more recently, owing to the growing threat of misusing AI tools. Finally, the study proposes policy interventions that will help ensure responsible conduct of research in African university settings.