Aggressive agents can significantly affect the durability of reinforced concrete structures. To ensure long-term performance, these materials must retain their integrity under such conditions, serving as a protective barrier against substances that could induce the corrosion of embedded reinforcements. Corrosion arises from carbonation and the action of chloride ions, which can penetrate into concrete through convection and diffusion mechanisms. Opuntia Ficus-Indica (OPI) has been used as a bio-inhibitor that also reduces the chloride ion penetration into cement-based matrices. This extract works by chemically bonding with water molecules, aggressive agents, and pectins, effectively blocking the pores within the concrete structure and enhancing its resistance to degradation. In this study, a high-early strength Portland cement was used for mortar production, with a water-to-cement ratio (w/c) of 0.5. Eight different mixtures were prepared: a reference mixture, four mixtures where OPI mucilage partially replaced the mixing water at proportions of 4%, 6%, 8%, and 10%, two mixtures where powdered OPI extract partially replaced the cement at proportions of 1% and 2%, and one mixture incorporating a commercial corrosion inhibitor. This study evaluated the influence of OPI extract content on the compressive strength of these mixtures, as well as on the chloride ion migration in the studied mortars, in accordance with the NT BUILD 492 standard. Results show that the use of OPI can reduce the rate of chloride ingress into concrete acting as an additional barrier to protect the reinforcement.