Uremia increases the risks of surgery and anesthesia, especially in the hepatobiliary setting, because of impaired fluid and electrolyte homeostasis, coagulation problems, and impaired immune response. Hemodialysis is essential for preparing such patients for surgery, as maintaining fluid balance is vital for reducing perioperative complications. Simple hepatic cysts necessitate treatment only when symptomatic. Treatment methods include percutaneous aspiration, sclerotherapy, and surgical fenestration, laparoscopic techniques being preferred due to lower morbidity. Polycystic liver disease is a rare genetic disorder, whose complications include cyst infection and rupture and compression of adjacent organs, necessitating intervention. The treatment principles are similar to those used for simple cysts, with liver resection being required only in selected cases. Normally, management strategies for hepatobiliary stones range from simple monitoring to surgical intervention, but in patients on hemodialysis specific endoscopic techniques are preferred to minimize complications. Overall, interaction among healthcare providers is essential for optimizing outcomes in uremic patients.