Increased investment, technological advancements, brand-new education initiatives, and strategic partnerships have all contributed to the rapid growth of the aerospace industry in Mexico and Latin America. As professionals in this field, your role is crucial in this growth. As the region continues to develop its aerospace capabilities, your expertise in implementing effective design methodologies becomes even more vital to the success of aerospace projects. These methodologies, including systems engineering, concurrent engineering, and agile development, are essential for managing the complexity of aerospace systems and ensuring that projects meet stringent safety, performance, and cost requirements. In the context of Mexican and Latin American aerospace projects, developing region-specific design methodologies will enhance the region's ability to compete globally. This chapter will explore the various applications of newly developed design methodologies in the Mexican aerospace sector, emphasizing their impact on project outcomes, collaboration, and technological advancement in the region.