Consent from the individual, or the individual’s representative, is one of the most fundamental legal and ethical principles of any healthcare intervention or treatment. Vaccination programmes rely on high levels of trust between the public and healthcare professionals providing vaccines. Obtaining informed consent prior to administering vaccines is an essential part of this relationship. Consent is a dialogic process between vaccinators and patients/parents/carers. This chapter will provide a practical application of consent guidance in real-life vaccination settings which are covered in Chap. 2 of the Green Book:  • Discuss the legal issues of consent.  • Discuss potential issues that may arise and how to manage them.  • Provide information on key resources. The broad principles of the law relating to consent are the same across the UK, but there are some legislative differences which, where relevant, are covered in this chapter. The RCN has three separate resources which further clarify the legislation on consent for nurses:  •  Consent in England and Wales  •  Consent in Northern Ireland  •  Consent in Scotland This chapter will set out the legal position for vaccinators, whether they are vaccinating adults or children and define the key principles underpinning consent, practically explore the consent process and discuss the management of issues that may arise in practice across all age groups using practice scenarios.