When bone reconstruction in fracture-related infection affecting a joint is considered impossible or unadvisable (F5), the available surgical options for limb salvage include endoprosthetic joint replacement, resection arthroplasty, and arthrodesis. Based on the scarce available literature, they are all aggressive procedures and associate high revision rates. Endoprosthetic joint replacement provides considerable short-term improvement, at the cost of high rates of failure in the medium term (mostly, due to infection recurrence). The FRI patients most likely to benefit from it are F5 R1–3 I1–4 patients in the FRI classification who are expected to have an active lifestyle after arthroplasty, in whom the structures needed for optimal prosthetic joint function are preserved (e.g., functional knee extensor mechanism) and in whom the estimated risk of postoperative recurrence is low. Resection arthroplasty candidates are mostly F5 R3–4 I1–4 with very low functional demands, and the most common site for excision arthroplasty after FRI is the hip. Arthrodesis often includes shortening to collapse the bone defect, and facilitates wound closure. It is an alternative to endoprosthetic joint replacement when it is not possible or unadvisable, and an alternative to amputation in patients who are unlikely to wear or would likely have lower functionality with an external prosthesis.