With the acceleration of industrialization and urbanization, wastewater pollution is becoming increasingly serious, threatening human health and the environment. High-salinity ammonia-nitrogen wastewater, generated from pharmaceutical wastewater, smelting wastewater, landfill leachate, aquaculture wastewater, etc., is a type of wastewater that is difficult to treat and poses a serious threat to the environment. Recently, with the rapid development of electrocatalytic technology, it has demonstrated excellent performance in treating High-salinity ammonia-nitrogen wastewater. However, there are few studies on their treatment performance on high-salinity ammonia-nitrogen wastewater. Therefore, the performance of Ti/IrO2–Ta2O5, Ti/IrO2-RuO2, and boron-doped diamond in the treatment of high-salinity ammonia-nitrogen wastewater is investigated. Meanwhile, the operation factors are optimized, such as plate spacing, current density, pH, cathode materials, and the energy consumption is evaluated. The results show that under optimized operating parameter conditions, the ammonia nitrogen removal rate can reach 100% appling the three anodes in the treatment of wastewater with 600 mg/L ammonia-nitrogen and 10,000 TDS, and the energy consumption is 0.0375 kW·h/g, 0.0749 kW·h/g, and 0.0300 kW·h/g respectively.