In the present work, research was conducted to investigate the mechanical properties of PLA (Polylactic Acid) structures fabricated via Fused Deposition Modeling (FDM), a popular 3D printing technique. The main objective of the research was to quantify the influence of key printing parameters, such as printing angle, layer height, layer width and extrusion temperature, on the mechanical properties of 3D printed PLA parts. The specimens which were printed at different angles (0°, 18°, 36°, 54°, 72°, and 90°) were subjected to tensile testing to evaluate their key performances such as tensile strength, elasticity, yield strength and fracture behavior. The Taguchi method was used to optimize the experimental procedure, this facilitated the identification of optimal combinations of printing parameters, leading to more consistent and reliable results. The study focused on understanding the relationship between printing parameters and the mechanical properties of PLA, providing useful information on how different manufacturing conditions affect the performance of the material. The results of this study provide valuable information for the additive manufacturing industry by further clarifying the mechanical behavior of PLA under different printing conditions. This information is very important in industries such as automotive and biomedical engineering, where knowledge of the material’s properties is crucial to the performance of parts printed using 3D technology. In addition, this work can lay the groundwork for future research aimed at optimizing the design and application of 3D printed components, potentially extending the use of PLA to advanced high-performance packaging.