Departing from the so-called maternal turn in contemporary artistic practice, this essay introduces readers to the central problematic driving the newly established research initiative The M/Other Project: Creativity, Procreation, and Contemporary Art at Leuphana Universität Lüneburg. The M/Other Project explores how artists—many of whom are also foregrounding their identity as mothers for the first time in history—are challenging the long-standing prohibition against the maternal as a site of biological and intellectual creation. With its roots in antiquity, this taboo has taken the form of a metaphor in which the maternal body is permitted only as an analogy for cultural production, never as an embodiment of it. That analogy is predicated on an alignment of “creation” with intellectual labor, which is then opposed to “procreation” as an issue of materiality or matter. Rejecting such oppositions, contemporary artists offer new paradigms of how we define both motherhood and artistic creation.