In recent decades, researchers have focused extensively on innovative technologies and strategies to mitigate the impact of seismic events on buildings. Structural failures due to seismic activities pose significant risks to buildings and their occupants. Therefore, designing buildings with modern techniques that can reduce the impact of seismic loads is crucial. This study examines the response of a G+4 structure under seismic loading, analysing three design variants: conventional design, viscous damper-enhanced design, and a combination of viscous damper and rubber base isolator design. Key parameters such as storey drift, overturning moment, storie displacement, and storie shear were assessed using analytical software to analyse the structural response. The findings indicate that the viscous damper-enhanced design absorbs seismic energy more effectively, reducing vibrations compared to the conventional design. Furthermore, the combination of viscous damper and base isolator design exhibited the lowest storey drift and deflection, significantly outperforming both the conventional and viscous damper-enhanced designs. This combined design not only enhances seismic performance but also improves occupant comfort and safety while extending the building’s lifespan, making it particularly beneficial for earthquake-prone areas. With the combination of advanced damping mechanisms with resilient structural elements, engineers can create sustainable building designs that effectively mitigate the impact of earthquakes. This integrated approach not only ensures buildings meet stringent safety standards but also minimizes downtime and repair costs associated with seismic events. Overall, the study highlights the distinct behaviours of different structural designs under seismic loading, demonstrating the effectiveness of damping and base-isolating techniques in ensuring safer building performance during earthquakes.