Lignin is a biopolymer derived from lignocellulosic biomass that has garnered significant interest for its potential in biomedical applications, due to its unique properties such as high carbon content, thermal stability, biodegradability, and biocompatibility. Recent research has focused on developing lignin-based composites and hybrid materials for various medical uses, including tissue engineering scaffolds, wound dressings, and drug delivery systems. These materials offer several advantages, such as cost-effective processing and low energy requirements, making them attractive for sustainable biomedical applications. However, challenges remain in optimizing their properties and ensuring consistent performance in clinical settings. This chapter aims to provide with a short review on lignin hybrid materials and composites for biomedical applications, including advantages, challenges and future perspective.