Sensory systems are our gateway for constructing an internal representation of the external world, translating diverse stimuli into a unified perceptual framework. This chapter focuses on the brain mechanisms underlying multisensory integration, emphasizing the role of visual processing in spatial representation. We explore how vision contributes to the development of spatial perception in both children and adults, examining its critical influence on constructing an accurate spatial framework. Then, we investigate how general neural mechanisms adapt in individuals with blindness to understand how spatial representation is built in the absence of vision. Finally, we examine the role of vision in regulating sleep and the emerging links between sleep processes and perception. By addressing how neural mechanisms adapt in blindness and investigating the connections between sleep and sensory integration, the discussion aims to provide a comprehensive understanding of the neural bases for spatial perception, its developmental and adaptive trajectories, and its relationship with sleep. Insights on future technological applications were also provided.